COBRA基因编码糖基磷脂酰肌醇锚定的植物特异性蛋白，在初生和次生细胞壁的纤维素生物合成中发挥重要作用。通过生物信息学方法，从玉米基因组中发现了9个COBRA家族基因，并对其基因结构、系统发育和表达模式等进行了分析。结果表明，9个COBRA家族基因都含有CCVS保守结构域，并且均定位于细胞膜上。系统进化分析结果显示，该家族可以分为2个亚族，每个亚族内的基因具有相似的基因结构和理化性质。基因表达分析结果表明，所有COBRA家族成员响应多种非生物胁迫，且当植株受到紫外照射处理时，ZmCOBL1～ZmCOBL3和ZmCOBL7～ZmCOBL9这6个基因均表现出上调应答。

The COBRA gene encodes a glycosyl phosphatidyl inositol-anchored， plant-specific protein that plays an important role in cellulose biosynthesis in primary and secondary cell walls. In this study， 9 COBRA family genes were found from the maize genome by bioinformatics methods， and their gene structures， phylogeny and expression patterns were analyzed. The results showed that the 9 COBRA family genes all contained CCVS conserved domains， and all of them were located on the cell membrane. Phylogenetic analysis showed that COBRA family could be divided into two subfamilies， and the genes in each subgroup had similar gene structure and physicochemical properties. Gene expression analysis showed that all COBRA family members responded to a variety of abiotic stresses， and all six genes， ZmCOBL1～ZmCOBL3 and ZmCOBL7～ZmCOBL9， showed up-regulated responses when plants were exposed to UV irradiation.

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国家自然科学基金面上项目(31771801、32072069)；湖北省高等学校优秀中青年科技创新团队计划项目(T201704)。